1 Four or more new ear infections within 1 year.
2 Two or more serious sinus infections within 1 year.
3 Two or more months on antibiotics with little effect.
4 Two or more pneumonias within 1 year.
5 Failure of an infant to gain weight or grow normally.
6 Recurrent, deep skin or organ abscesses.
7 Persistent thrush in mouth or fungal infection on skin.
8 Need for intravenous antibiotics to clear infections.
9 Two or more deep-seated infections including septicemia.
10 A family history of PI.