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Common Variable Immunodeficiency (CVID) is a primary immunodeficiency caused by a variety of different genetic abnormalities that causes the immune system to not produce normal amounts of antibodies. Having CVID makes you prone to recurrent infections, autoimmune disorders, organ damage and cancer. Early diagnosis is vital to improving outcomes for adolescents. 


Our website is built on the belief that education and awareness are important tools to help identify CVID signs and symptoms in your child that can ultimately lead to an early diagnosis. By offering educational resources and advocating tips, we help you take steps toward ensuring your child receives timely and effective care. 



There is no cure for common variable immunodeficiency but ​it can be managed with ongoing treatment. 
Treatment options can range from Prophylactic antibiotics to Stem Cell transplant. 

The standard treatment for CVID is immunoglobulin replacement therapy. 
Immunoglobulin therapy is made from donated human plasma (the liquid component of blood that contains antibodies.)

Infusions can be administered intravenously (IVIG) or subcutaneously (SCIG) 
1 Four or more new ear infections within 1 year.
 2 Two or more serious sinus infections within 1 year. 
3 Two or more months on antibiotics with little effect. 
4 Two or more pneumonias within 1 year.
 5 Failure of an infant to gain weight or grow normally. 
6 Recurrent, deep skin or organ abscesses. 
7 Persistent thrush in mouth or fungal infection on skin. 
8 Need for intravenous antibiotics to clear infections. 
9 Two or more deep-seated infections including septicemia. 
10 A family history of PI.
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